?-312 Helical Rotamers

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C3 C2
?1 ?2 ?1 ?2 ?1 ?2 ?1 ?2

The pitch of the 312 helix (roughly 2.7 residues per turn), while slightly greater than the 314 helix, results in a helical motif reminicent of the &alpha-helix. Like the 314 helix, the 312 helix also prefers two particular substitution patterns. Both the L - C3 (green) and D - C2 (magenta) result in equatorial positioning of sidechain R groups. Notably, the helical dipole moment of the 312 helix is opposite of the 314 and aligns with the dipole moment of the &alpha-helix.